Suaeda glauca Attenuates Liver Fibrosis in Mice by Inhibiting TGFβ1-Smad2/3 Signaling in Hepatic Stellate Cells.

ABSTRACT: Chronic liver injury due to various hepatotoxic stimuli commonly leads to fibrosis, which is a crucial factor contributing to liver disease-related mortality. Despite the potential benefits of Suaeda glauca (S. glauca) as a natural product, its biological and therapeutic effects are barely known. This study investigated the effects of S. glauca extract (SGE), obtained from a smart farming system utilizing LED lamps, on the activation of hepatic stellate cells (HSCs) and the development of liver fibrosis. C57BL/6 mice received oral administration of either vehicle or SGE (30 or 100 mg/kg) during CCl₄ treatment for 6 weeks. The supplementation of SGE significantly reduced liver fibrosis induced by CCl₄ in mice as evidenced by histological changes an

SUBMITTER: Hong YJ 

PROVIDER: S-EPMC10490352 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature