Effect of Immune-Modulatory Interventions on Asymptomatic Cytomegalovirus Shedding During Suppressive Antiretroviral Therapy.
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ABSTRACT:
SUBMITTER: Hastie E
PROVIDER: S-EPMC10490531 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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Effect of Immune-Modulatory Interventions on Asymptomatic Cytomegalovirus Shedding During Suppressive Antiretroviral Therapy.
Hastie Elizabeth E Moser Carlee C Sun Xin X Lennox Jeffrey J Hsue Priscilla Y PY Bosch Ronald J RJ Deeks Steven S Meneses Milenka V MV Lederman Michael M MM Hunt Peter P Henrich Timothy J TJ Marconi Vincent C VC Gianella Sara S
The Journal of infectious diseases 20230601 1
Long-term consequences of human immunodeficiency virus (HIV) are likely the result of persistent inflammation and immune dysfunction of which cytomegalovirus (CMV) is a known contributor. We leveraged 2 AIDS Clinical Trials Group clinical trials exploring the effects of immune modulators (ruxolitinib and sirolimus) on inflammation in people with HIV on antiretroviral therapy to determine whether these interventions affected CMV shedding at various mucosal sites. Analyzing 635 mucosal samples col ...[more]
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