Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework.

ABSTRACT:

Introduction

We develop a framework to model disease progression across Alzheimer's disease (AD) and to assess the cost-effectiveness of future disease-modifying therapies (DMTs) for people with mild cognitive impairment (MCI) due to AD.

Methods

Using data from the US National Alzheimer's Coordinating Center, we apply survival analysis to estimate transition from predementia to AD dementia and ordered probit regression to estimate transitions across AD dementia stages. We investigate the cost-effectiveness of a hypothetical treatment scenario for people in MCI due to AD.

Results

We present an open-access model-based decision-analytic framework. Assuming a modest DMT treatment effect in MCI, we predict extended life expectancy and a reduction in time with AD dementia.<

SUBMITTER: Green C 

PROVIDER: S-EPMC10490554 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature