A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain.

ABSTRACT: Thigmotaxis is an innate predator avoidance behaviour of rodents. To gain insight into how injury and disease models, and analgesic drug treatments affect thigmotaxis, we performed a systematic review and meta-analysis of studies that assessed thigmotaxis in the open field test. Systematic searches were conducted of 3 databases in October 2020, March and August 2022. Study design characteristics and experimental data were extracted and analysed using a random-effects meta-analysis. We also assessed the correlation between thigmotaxis and stimulus-evoked limb withdrawal. This review included the meta-analysis of 165 studies We report thigmotaxis was increased in injury and disease models associated with persistent pain and this increase was attenuated by analgesic drug treatments in both ra

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC10490990 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature