The core role of macrophages in hepatocellular carcinoma: the definition of molecular subtypes and the prognostic risk system.

ABSTRACT: Background: In patients with hepatocellular carcinoma (HCC), the tumor microenvironment (TME) is resistant to immunotherapy because of its specificity. It is meaningful to explore the role of macrophage, which is one of the most abundant immune cells in the TME, in cellular communication and its effect on the prognosis and immunotherapy of HCC. Methods: Dimensionality reduction and clustering of the single-cell RNA-seq data from the GSE149614 dataset were carried out to identify the cellular composition of HCC. CellChat was used to analyze the communication between different cells. The specifically highly expressed genes of macrophages were extracted for univariate Cox regression analysis to obtain prognostic genes for HCC cluster analysis, and the risk system of macrophage-s

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10491020 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature