Dataset Information

Anthropometry of deep-set eyes with respect to difficulty in docking during femtosecond laser procedures.

ABSTRACT:

Purpose

To identify the facial anthropometric parameters that predict the difficulty during femtosecond (FS) laser.

Methods: this was a

single-center observational study was conducted on participants between the ages 18 and 30 years who were planned for FS-LASIK (femtosecond laser-assisted laser in situ keratomileusis) or SMILE (small incision lenticule extraction) at Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. The front and side-facing images of the participants were analyzed using Image J software to measure different anthropometric parameters. The nasal bridge index, facial convexity, and other parameters were measured. The difficulty faced by the surgeon during docking was recorded for each subject. The data were analyzed on Stata 14.

Results

A total of 97 subjects were included. The mean age was 24 (±7) years. Twenty-three (23.71%) subjects were females while the rest were males. Difficulty in docking was seen in 1 (4.34%) female and 14 (19%) males. The mean nasal bridge index was 92.58 (±4.01) in subjects with deep-set eyes and 89.72 (±4.30) in normal subjects. The mean total facial convexity was 129.28 (±4.24) in deep-set eyes, and 140.23 (±4.74) in normal subjects.

Conclusion

Total facial convexity appeared as the most important feature, with the value being less than 133° in most subjects with unfavorable facial anthropometry.

SUBMITTER: Khokhar S

PROVIDER: S-EPMC10491051 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Anthropometry of deep-set eyes with respect to difficulty in docking during femtosecond laser procedures.

Khokhar Sudarshan S Rani Deeksha D Rathod Aishwarya A Nathiya Venkatesh V Nayak Shreya S Pujari Amar A Kumar Saumya S Sharma Tushar T

Indian journal of ophthalmology 20230701 7

<h4>Purpose</h4>To identify the facial anthropometric parameters that predict the difficulty during femtosecond (FS) laser.<h4>Methods: this was a</h4>single-center observational study was conducted on participants between the ages 18 and 30 years who were planned for FS-LASIK (femtosecond laser-assisted laser in situ keratomileusis) or SMILE (small incision lenticule extraction) at Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. The front and side-facing images of t ...[more]

PMID: 37417109

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Project description:Airway organoids derived from adult murine epithelial cells represent a complex 3D in vitro system mimicking the airway epithelial tissue’s native cell composition and physiological properties. In combination with a precise damage induction via femtosecond laser-based nanosurgery, this model allows for the examination of intra- and intercellular dynamics in the course of repair processes with a high spatio-temporal resolution, which can hardly be reached using in vivo approaches. For characterization of the organoids’ response to single or multiple-cell ablation, we first analyzed overall organoid survival and found that airway organoids were capable of efficiently repairing damage induced by femtosecond laser-based ablation of a single to ten cells within 24 h. An EdU staining assay further revealed a steady proliferative potential of airway organoid cells. Especially in the case of ablation of five cells, proliferation was enhanced within the first four hours upon damage induction, whereas ablation of ten cells was followed by a slight decrease in proliferation within this time frame. Analyzing individual trajectories of single cells within airway organoids, we found an increased migratory behavior in cells within close proximity to the ablation site following the ablation of ten, but not five cells. Bulk RNA sequencing and subsequent enrichment analysis revealed the differential expression of sets of genes involved in the regulation of epithelial repair, distinct signaling pathway activities such as Notch signaling, as well as cell migration after laser-based ablation. Together, our findings demonstrate that organoid repair upon ablation of ten cells involves the same key processes by which native airway epithelial wound healing is regulated. This marks the herein presented in vitro damage model suitable to study repair processes following acute airway injury, thereby posing a novel approach to gain insights into the mechanisms driving epithelial repair on a single-cell level.

Dataset Information

Anthropometry of deep-set eyes with respect to difficulty in docking during femtosecond laser procedures.

Purpose

Methods: this was a

Results

Conclusion

Publications

Anthropometry of deep-set eyes with respect to difficulty in docking during femtosecond laser procedures.

Similar Datasets

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