Modulation of riboflavin biosynthesis and utilization in mycobacteria.

ABSTRACT: Riboflavin (vitamin B₂) is the precursor of the flavin coenzymes, FAD and FMN, which play a central role in cellular redox metabolism. While humans must obtain riboflavin from dietary sources, certain microbes, including Mycobacterium tuberculosis (Mtb), can biosynthesize riboflavin de novo. Riboflavin precursors have also been implicated in the activation of mucosal-associated invariant T (MAIT) cells which recognize metabolites derived from the riboflavin biosynthesis pathway complexed to the MHC-I-like molecule, MR1. To investigate the biosynthesis and function of riboflavin and its pathway intermediates in mycobacterial metabolism, physiology and MAIT cell recognition, we constructed conditional knockdowns (hypomorphs) in riboflavin biosynthesis and utilization

SUBMITTER: Chengalroyen MD 

PROVIDER: S-EPMC10491194 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature