Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.

ABSTRACT: Progression through the cell cycle is controlled by regulated and abrupt changes in phosphorylation.¹ Mitotic entry is initiated by increased phosphorylation of mitotic proteins, a process driven by kinases,² while mitotic exit is achieved by counteracting dephosphorylation, a process driven by phosphatases, especially PP2A:B55.³ While the role of kinases in mitotic entry is well-established, recent data have shown that mitosis is only successfully initiated when the counterbalancing phosphatases are also inhibited.⁴ For PP2A:B55, inhibition is achieved by the two intrinsically disordered proteins (IDPs), ARPP19 (phosphorylation-dependent)^6,7 and FAM122A⁵ (inhibition is phosphorylation-independent). Despite their critical ro

SUBMITTER: Padi SKR 

PROVIDER: S-EPMC10491220 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature