An efficient and robust ABC approach to infer the rate and strength of adaptation.

ABSTRACT: Inferring the effects of positive selection on genomes remains a critical step in characterizing the ultimate and proximate causes of adaptation across species, and quantifying positive selection remains a challenge due to the confounding effects of many other evolutionary processes. Robust and efficient approaches for adaptation inference could help characterize the rate and strength of adaptation in non-model species for which demographic history, mutational processes, and recombination patterns are not currently well-described. Here, we introduce an efficient and user-friendly extension of the McDonald-Kreitman test (ABC-MK) for quantifying long-term protein adaptation in specific lineages of interest. We characterize the performance of our approach with forward simulations and find tha

SUBMITTER: Murga-Moreno J 

PROVIDER: S-EPMC10491248 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature