Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis.

ABSTRACT: The function of some genetic variants associated with brain-relevant traits has been explained through colocalization with expression quantitative trait loci (eQTL) conducted in bulk post-mortem adult brain tissue. However, many brain-trait associated loci have unknown cellular or molecular function. These genetic variants may exert context-specific function on different molecular phenotypes including post-transcriptional changes. Here, we identified genetic regulation of RNA-editing and alternative polyadenylation (APA), within a cell-type-specific population of human neural progenitors and neurons. More RNA-editing and isoforms utilizing longer polyadenylation sequences were observed in neurons, likely due to higher expression of genes encoding the proteins mediating these post-transcrip

SUBMITTER: Aygun N 

PROVIDER: S-EPMC10491258 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature