Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells.

ABSTRACT: Most humans have a lifelong imperceptible BK Polyomavirus (BKPyV) infection in epithelial cells lining the reno-urinary tract. In kidney transplant recipients, unrestricted high-level replication of donor-derived BKPyV in the allograft underlies polyomavirus-associated nephropathy, a condition with massive epithelial cell loss and inflammation causing premature allograft failure. There is limited understanding on how BKPyV disseminates throughout the reno-urinary tract and sometimes causes kidney damage. Tubule epithelial cells are tightly connected and have unique apical and basolateral membrane domains with highly specialized functions but all in vitro BKPyV studies have been performed in non-polarized cells. We therefore generated a polarized cell model of primary renal proximal tubule

SUBMITTER: Lorentzen EM 

PROVIDER: S-EPMC10491296 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature