Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein.

ABSTRACT: The transmissible spongiform encephalopathies are a heterogeneous group of fatal neurodegenerative disorders occurring in humans, mink, cats, and ruminant herbivores. The occurrence of novel transmissible spongiform encephalopathies in cattle in the United Kingdom and Europe and in mule deer and elk in parts of the United States has emphasized the need for reliable diagnostic tests with standardized reagents. Postmortem diagnosis is performed by histologic examination of brain sections from affected animals. The histopathological criteria for transmissible spongiform encephalopathies include gliosis, astrocytosis, neuronal degeneration, and spongiform change. These lesions vary in intensity and anatomic location depending on the host species and genetics, stage of disease, and infectious a

SUBMITTER: O'Rourke KI 

PROVIDER: S-EPMC104913 | biostudies-literature | 1998 Jun

REPOSITORIES: biostudies-literature