Antimicrobial prophylaxis for vesicoureteral reflux: which subgroups of children benefit the most?

ABSTRACT:

Background

While the Randomized Intervention for children with Vesicoureteral Reflux (RIVUR) trial found that long-term antimicrobial prophylaxis reduced the risk of urinary tract infection (UTI) recurrences by 50%, 10 children had to be treated with long-term antimicrobial prophylaxis for one to benefit (i.e., observed number needed to treat (NNT) of 10). Accordingly, we re-analyzed RIVUR data to systematically identify subgroups of children with vesicoureteral reflux (VUR) with a smaller NNT.

Methods

Using patient-level data from the RIVUR trial, we applied penalized regression methods including the baseline age, VUR, and bowel-bladder dysfunction (BBD) as covariates to identify subgroups that consider the trade-off between absolute risk difference and size.

Results

SUBMITTER: Zhao B 

PROVIDER: S-EPMC10491336 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature