Clinical and genetic insights of Parkinson's Disease in a Mexican cohort: highlighting Latino's diversity.

ABSTRACT:

Objective

This study aims to describe the establishment of the Mexican Parkinson's Research Network (MEX-PD), a consortium dedicated to investigating the clinical, genetic, environmental, and neurophysiological underpinnings of phenotypic diversity in Mexican Parkinson's disease (PD) patients and to present preliminary clinical and genetic outcomes.

Methods

PD patients and control participants were recruited from medical centers across Mexico. The initial recruitment phase involved comprehensive neurological evaluations, cognitive assessments, and DNA collection. We conducted classical statistical analyses on clinical variables. Secondly, following genotyping with NeuroBooster array, quality control and imputation, preliminary analysis of ancestry composition, allele frequen

SUBMITTER: Lazaro-Figueroa A 

PROVIDER: S-EPMC10491355 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature