Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease.

ABSTRACT: Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human postmortem brain RNA-seq datasets using both within-region and pan-regional frameworks. We find evidence of sex-biased transcription in many autosomal genes, some of which provide evidence for pathways and cell population differences between chromosomally male and female individuals. These analyses also highlight regional differences in the extent of sex-differential gene expression. We observe an increase in specific neuronal transcripts in male brains and an increase in immune and glial function-related transcripts in female brains. Integration with single-cell d

SUBMITTER: Fass SB 

PROVIDER: S-EPMC10491382 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature