DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection.

ABSTRACT: Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest known risk factor for severe disease upon secondary infection with a heterologous serotype, a risk which increases as serotypes co-circulate in endemic regions. This disease risk is thought to be mediated by IgG-isotype antibodies raised during a primary infection, which poorly neutralize heterologous DENV serotypes and instead opsonize virions for uptake by FcγR-bearing cells. This antibody-dependent enhancement (ADE) of infection leads to a larger proportion of susceptible cells infected, higher viremia and greater immunopathology. We have previously chara

SUBMITTER: Wegman AD 

PROVIDER: S-EPMC10491401 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature