Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC10491636 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Zhang Lu L Yang Peichang P Chen Jingxuan J Chen Zhiqiang Z Liu Zhihui Z Feng Gaoqing G Sha Fangfang F Li Zirui Z Xu Zaoyi Z Huang Yating Y Shi Xiaotong X Li Xuebiao X Cui Jiatian J Zhang Chenyi C Fan Pei P Cui Liuqing L Shen Yunpeng Y Zhou Guangzhou G Jing Hongjuan H Ma Shiwei S
Nature communications 20230908 1
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in vascular endothelial cells (VECs) remain unclear. Here, we identify a crucial role for CD44, a multifunctional adhesion molecule, in controlling autophagy and ageing in VECs. The CD44 intercellular domain (CD44ICD) negatively regulates autophagy by reducing PIK3R4 and PIK3C3 levels and disrupting STAT3-dependent PtdIns3K complexes. CD44 and it ...[more]