Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.

ABSTRACT: Synaptogenesis is essential for circuit development; however, it is unknown whether it is critical for the establishment and performance of goal-directed voluntary behaviors. Here, we show that operant conditioning via lever-press for food reward training in mice induces excitatory synapse formation onto a subset of anterior cingulate cortex neurons projecting to the dorsomedial striatum (ACC_→DMS). Training-induced synaptogenesis is controlled by the Gabapentin/Thrombospondin receptor α2δ-1, which is an essential neuronal protein for proper intracortical excitatory synaptogenesis. Using germline and conditional knockout mice, we found that deletion of α2δ-1 in the adult ACC_→DMS circuit diminishes training-induced excitatory synaptogenesis. Surprisingly, this manipulat

SUBMITTER: Ulloa Severino FP 

PROVIDER: S-EPMC10491649 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature