VMHdm/c^SF-1 neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive.

ABSTRACT:

Objective

To adapt to metabolically challenging environments, the central nervous system (CNS) orchestrates metabolism of peripheral organs including skeletal muscle. The organ-communication between the CNS and skeletal muscle has been investigated, yet our understanding of the neuronal pathway from the CNS to skeletal muscle is still limited. Neurons in the dorsomedial and central parts of the ventromedial hypothalamic nucleus (VMHdm/c) expressing steroidogenic factor-1 (VMHdm/c^SF-1 neurons) are key for metabolic adaptations to exercise, including increased basal metabolic rate and skeletal muscle mass in mice. However, the mechanisms by which VMHdm/c^SF-1 neurons regulate skeletal muscle function remain unclear. Here, we show that VMHdm/c^SF-1 neuro

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC10491730 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature