Vault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities.

ABSTRACT: The physicochemical characteristics of RNA admit non-coding RNAs to perform a different range of biological acts through various mechanisms and are involved in regulating a diversity of fundamental processes. Notably, some reports of pathological conditions have proved abnormal expression of many non-coding RNAs guides the ailment. Vault RNAs are a class of non-coding RNAs containing stem regions or loops with well-conserved sequence patterns that play a fundamental role in the function of vault particles through RNA-ligand, RNA-RNA, or RNA-protein interactions. Taken together, vault RNAs have been proposed to be involved in a variety of functions such as cell proliferation, nucleocytoplasmic transport, intracellular detoxification processes, multidrug resistance, apoptosis, and autophagy,

SUBMITTER: Aghajani Mir M 

PROVIDER: S-EPMC10491885 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature