Optimal selection of suitable templates in protein interface prediction.

ABSTRACT:

Motivation

Molecular-level classification of protein-protein interfaces can greatly assist in functional characterization and rational drug design. The most accurate protein interface predictions rely on finding homologous proteins with known interfaces since most interfaces are conserved within the same protein family. The accuracy of these template-based prediction approaches depends on the correct choice of suitable templates. Choosing the right templates in the immunoglobulin superfamily (IgSF) is challenging because its members share low sequence identity and display a wide range of alternative binding sites despite structural homology.

Results

We present a new approach to predict protein interfaces. First, template-specific, informative evolutionary profiles are establ

SUBMITTER: Grudman S 

PROVIDER: S-EPMC10491951 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature