Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.

ABSTRACT:

Introduction

Meteorin-like hormone (Metrnl) is ubiquitously expressed in skeletal muscle, heart, and adipose with beneficial roles in obesity, insulin resistance, and inflammation. Metrnl is found to protect against cardiac hypertrophy and doxorubicin-induced cardiotoxicity. However, its role in diabetic cardiomyopathy (DCM) is undefined.

Objectives

We aimed to elucidate the potential roles of Metrnl in DCM.

Methods

Gain- andloss-of-function experimentswere utilized to determine the roles of Metrnl in the pathological processes of DCM.

Results

We found that plasma Metrnl levels, myocardial Metrnl protein and mRNA expressions were significantly downregulated in both streptozotocin (STZ)-induced (T1D) mice and leptin receptor deficiency (db/db) (T2D) mice. Cardia

SUBMITTER: Lu QB 

PROVIDER: S-EPMC10491969 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature