Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke.

ABSTRACT:

Introduction

Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 is known as a key growth suppressor in proliferating cells. However, its role in neuronal cells after stroke remains unclear.

Objective

We aimed to investigate the mechanistic role of Maf1 in spontaneous neural repair and evaluated the therapeutic effect of targeting Maf1 on stroke recovery.

Methods

We used mouse primary neurons to determine the signaling mechanism of Maf1, and the cleavage-under-targets-and-tagmentation-sequencing to map the whole-genome promoter binding sites of Maf1 in isolated mature cortical neurons. Photothrombotic stroke model was used to determine the therapeutic effect on neural repair and funct

SUBMITTER: Tsang CK 

PROVIDER: S-EPMC10491990 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature