Extracellular matrix in skin diseases: The road to new therapies.

ABSTRACT:

Background

The extracellular matrix (ECM) is a vital structure with a dynamic and complex organization that plays an essential role in tissue homeostasis. In the skin, the ECM is arranged into two types of compartments: interstitial dermal matrix and basement membrane (BM). All evidence in the literature supports the notion that direct dysregulation of the composition, abundance or structure of one of these types of ECM, or indirect modifications in proteins that interact with them is linked to a wide range of human skin pathologies, including hereditary, autoimmune, and neoplastic diseases. Even though the ECM's key role in these pathologies has been widely documented, its potential as a therapeutic target has been overlooked.

Aim of review

This review discusses the molecul

SUBMITTER: Malta MD 

PROVIDER: S-EPMC10491993 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature