Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice.

ABSTRACT:

Objectives

Myocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post-MI is a primary contributor to progressive cardiac dysfunction, and ultimately heart failure. Currently, there are no approved drugs for the prevention or the reversal of cardiac fibrosis. Therefore, we tested the therapeutic potential of repurposed mesalazine as a post-MI therapy, as distinct antifibrotic effects have recently been demonstrated.

Methods

At 8 weeks of age, MI was induced in male C57BL/6J mice by LAD ligation. Mesalazine was administered orally at a dose of 100 μg/g body weight in drinking water. Fluid intake, weight development, and cardi

SUBMITTER: Kunzel SR 

PROVIDER: S-EPMC10492006 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature