CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis.

ABSTRACT:

Objective

Osteoarthritis (OA) is a non-inflammatory degenerative joint disease that mainly involves articular cartilage damage and involves the whole joint tissue. However, the relationship between CD14 and CSF1R and osteoarthritis remains unclear. The aim of this study was to explore the important role of CD14 and CSF1R in osteoarthritis and provide a new direction for its prevention and treatment.

Method

The osteoarthritis datasets GSE46750 and GSE82107 were downloaded from gene expression omnibus (GEO) database generated by GPL10558 and GPL570. R package limma was used to screen differentially expressed genes (DEDs). Weighted gene co-expression network analysis (WGCNA) was performed. The construction and analysis of a protein-protein interaction (PPI) network, functional

SUBMITTER: Zheng M 

PROVIDER: S-EPMC10492034 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature