Wound healing potential of Acacia catechu in streptozotocin-induced diabetic mice using in vivo and in silico approach.

ABSTRACT:

Background and aim

Acacia catechu Wild. (Fabaceae) barks are traditionally used in the treatment of diabetes and wounds. Therefore, the objective of the present study was to evaluate the wound healing potential of the alcoholic extract of A. catechu (EAC) in streptozotocin-induced diabetic mice.

Experimental procedures

EAC was first subjected to phytochemical estimations and standardization using (-) epicatechin as marker with the help of HPLC. Diabetes was induced in mice using streptozotocin and the wound healing potential of EAC was evaluated using excision and incision wound models on topical and oral treatment. Various biochemical parameters, in vivo antioxidants, cytokine profiling, VEGF, and histopathological examination were also performed

SUBMITTER: Nakhate VP 

PROVIDER: S-EPMC10492149 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature