Influence of blood phenylalanine level variations on the development of executive functions and social cognition in children with phenylketonuria.

ABSTRACT:

Objective

To investigate the performance of 27 children with phenylketonuria (PKU) in tests of Executive Functions (EF) and Social Cognition (SC), and their associations with metabolic control inferred by phenylalanine (Phe) levels.

Methods

The PKU group was dichotomized according to baseline Phe-levels into; "classical PKU"(n = 14), with Phe-levels above 1200 μmol/L (> 20 mg/dL); and "mild PKU" (n = 13) with Phe-between 360 and 1200 μmol/L (6-20 mg/dL). The neuropsychological assessment focused on the EF and SC subtests of the NEPSY-II battery and intellectual performance. Children were compared to age-matched healthy participants.

Results

Participants with PKU presented significantly lower Intellectual Quotient (IQ) compared to controls (p = 0.001). Regarding EF ana

SUBMITTER: de Almeida Duarte CM 

PROVIDER: S-EPMC10492152 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature