Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression.

ABSTRACT:

Background

Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME). Neutrophil extracellular traps (NETs), which can be generated by persistent inflammation, have been recently considered to be significant contributors in promoting cancer progression. However, whether NETs are implicated in Fn-related carcinogenesis is still poorly characterized. Here, we explored the role of NETs in Fn-related CRC as well as their potential clinical significance.

Methods

Fn was measured in tissue specimens and feces samples from CRC patients. The expression of NET markers were also detected in tissue specimens, freshly isolated neutrophils and blood serum from CRC patients, and the correlation

SUBMITTER: Kong X 

PROVIDER: S-EPMC10492297 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature