Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population.

ABSTRACT:

Background

The relationship of glucosamine use with incident dementia in the older population remains uncertain. We aimed to evaluate the longitudinal association between habitual glucosamine supplement and the risk of cause-specific dementia and examine the possible effect modifiers on this association.

Methods

The study included 214,945 participants over the age of 60 who had available information on glucosamine use and did not have dementia at baseline in the UK Biobank. The APOE genotypes were determined by a combination variant of rs429358 and rs7412. The primary outcome was incident vascular dementia, incident Alzheimer's disease, and incident frontotemporal dementia, respectively.

Results

Over a median follow-up duration of 12 years, 1039, 1774, and 122 partici

SUBMITTER: Zhou C 

PROVIDER: S-EPMC10492372 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature