Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report.

ABSTRACT:

Background

Insulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis.

Methods

We enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pa

SUBMITTER: Ambrozova L 

PROVIDER: S-EPMC10492455 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature