Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples.

ABSTRACT:

Background

Immature platelets (IP) are the youngest circulating platelets, released from megakaryocytes, and demonstrating increased dimensions, significant RNA content, and enhanced activity. Immature platelet research focuses on a differential diagnostic help in patients with thrombocytopenia. The objectives of this study were to compare the variability of IP in citrate and EDTA samples, and to determine stability over time.

Methods

Fifty-six patients were included for comparison between EDTA and citrate whole blood sample collection. Among the patients, 28 had thrombocytopenia (platelet count < 150G/L). Platelet measurement impedancemetry and fluorimetry were performed with Sysmex XN-9000. The immature platelet fraction (IPF) and absolute immature platelet count (A-IPC) w

SUBMITTER: Noel MM 

PROVIDER: S-EPMC10492457 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature