Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort.

ABSTRACT:

Background

Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce.

Objectives

To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort.

Design

Cross-sectional analysis within a multicenter observational study.

Methods

Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were availabl

SUBMITTER: Salmen A 

PROVIDER: S-EPMC10492471 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature