In vitro activity of hyaluronic acid and human serum on periodontal biofilm and periodontal ligament fibroblasts.

ABSTRACT:

Objectives

A beneficial effect of cross-linked hyaluronic acid (cHA) on periodontal wound healing and regeneration has recently been demonstrated. The present in vitro study was designed to obtain deeper knowledge on the effect of cHA when applied in the gingival sulcus (serum-rich environment) during non-surgical periodontal therapy.

Materials and methods

The influence of cHA, human serum (HS), and cHA/HS on (i) a 12-species biofilm formation, (ii) the adhesion of periodontal ligament fibroblasts (PDLF) to dentine surface, (iii) the expression and secretion of interleukin-8, and (iv) the expression of receptors of HA in PDLF and gingival fibroblasts (GF) were evaluated.

Results

At 4 h of biofilm formation, cHA and HS in combination (cHA/HS) slightly decreased the col

SUBMITTER: Zhu X 

PROVIDER: S-EPMC10492760 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature