Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice.

ABSTRACT: Cerebellar climbing fibers convey sensorimotor information and their errors, which are used for motor control and learning. Furthermore, they represent reward-related information. Despite such functional diversity of climbing fiber signals, it is still unclear whether each climbing fiber conveys the information of single or multiple modalities and how the climbing fibers conveying different information are distributed over the cerebellar cortex. Here we perform two-photon calcium imaging from cerebellar Purkinje cells in mice engaged in a voluntary forelimb lever-pull task and demonstrate that climbing fiber responses in 68% of Purkinje cells can be explained by the combination of multiple behavioral variables such as lever movement, licking, and reward delivery. Neighboring Purkinje cells

SUBMITTER: Ikezoe K 

PROVIDER: S-EPMC10492837 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature