Dataset Information

Genetic polymorphisms in the C19orf66 gene influenced HIV-1 infection in a Yunnan population.

ABSTRACT:

Background

Due to the deficiencies of vaccines and effective medicine, the human immunodeficiency virus (HIV) infection mechanism should be studied. The C19orf66 gene, one of the interferon-stimulated genes (ISGs), expresses broad-spectra anti-viral activity, including inhibiting HIV replication.

Methods

In this study, we collect 421 HIV-1 infected patients and 448 controls to genotype three SNPs in the C19orf66 gene. Then, the association between SNPs and biochemical indices/ HIV-1 subtypes are analyzed.

Results

Genotypes CC and CT of rs12611087 show statistically lower and higher frequencies in HIV-1 infected patients than in controls, respectively. Alleles C and T of rs12611087 play protective and risk roles in Yunnan HIV population, respectively. Biochemical indices analysis shows that HIV-1 infected persons carried genotype TT of rs77076061 express significantly lower CD3⁺/CD45⁺ ratio level and higher IBIL level. The epidemic subtypes of HIV-1 patients in this study are CRF 07_BC and CRF 08_BC. Moreover, subtype CRF 08_BC tends to infect persons with genotype CC of rs12611087.

Conclusion

The genetic polymorphisms of the C19orf66 gene are firstly studied and reported to associate with HIV-1 infection and biochemical indices of patients in Yunnan. Furthermore, subtype CRF 08_BC infection could be influenced by genotypes of SNP in the C19orf66 gene.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC10493081 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Genetic polymorphisms in the <i>C19orf66</i> gene influenced HIV-1 infection in a Yunnan population.

Zhang Yaxiang Y Feng Yue Y Liu Yang Y Liu Li L Xia Xueshan X Zhang A-Mei AM

PeerJ 20230907

<h4>Background</h4>Due to the deficiencies of vaccines and effective medicine, the human immunodeficiency virus (HIV) infection mechanism should be studied. The <i>C19orf66</i> gene, one of the interferon-stimulated genes (ISGs), expresses broad-spectra anti-viral activity, including inhibiting HIV replication.<h4>Methods</h4>In this study, we collect 421 HIV-1 infected patients and 448 controls to genotype three SNPs in the <i>C19orf66</i> gene. Then, the association between SNPs and biochemica ...[more]

PMID: 37701839

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