Gene editing for dyslipidemias: New tools to "cut" lipids.

ABSTRACT: Effective lipid lowering therapies are essential for the prevention of atherosclerosis and cardiovascular disease. Available treatments have evolved in both their efficacy and their frequency of administration, and currently include monoclonal antibodies, antisense oligonucleotides and siRNA approaches. However, an unmet need remains for more effective and long-lasting therapeutics. Gene editing permanently alters endogenous gene expression and has the potential to revolutionize disease treatment. Despite the existence of several gene editing approaches, the CRISPR/Cas9 system has emerged as the preferred technology because of its high efficiency and relative simplicity. This review provides a general overview of this promising technology and an update on the progress made towards the deve

SUBMITTER: Stankov S 

PROVIDER: S-EPMC10493168 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature