Identification of drug repurposing candidates for the treatment of anxiety: A genetic approach.

ABSTRACT: Anxiety disorders are a group of prevalent and heritable neuropsychiatric diseases. We previously conducted a genome-wide association study (GWAS) which identified genomic loci associated with anxiety; however, the biological consequences underlying the genetic associations are largely unknown. Integrating GWAS and functional genomic data may improve our understanding of the genetic effects on intermediate molecular phenotypes such as gene expression. This can provide an opportunity for the discovery of drug targets for anxiety via drug repurposing. We used the GWAS summary statistics to determine putative causal genes for anxiety using MAGMA and colocalization analyses. A transcriptome-wide association study was conducted to identify genes with differential genetically regulated levels of

SUBMITTER: Woodward DJ 

PROVIDER: S-EPMC10493169 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature