Evaluation of neural innervation in the human conventional outflow pathway distal to Schlemm's canal.

ABSTRACT: The distal outflow pathway of the human eye consists of the outer wall of Schlemm's canal, collector channels, and the deep-scleral, mid-scleral and episcleral vessels. It is the last region of transit for aqueous humor before returning to the venous system. While the trabecular meshwork, scleral spur, and inner wall of Schlemm's canal have been extensively analyzed to define their contributions to aqueous outflow, the role of the distal outflow pathway is not completely understood. Collector channels, emanating from Schlemm's canal were previously thought to be passive conduits for aqueous humor. However, recent studies have shown many collector channels contain flap-like appendages which move with changes in pressure. These findings, along with studies demonstrating innervation of episcl

SUBMITTER: Hann CR 

PROVIDER: S-EPMC10493174 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature