The association of white matter connectivity with prevalence, incidence and course of depressive symptoms: The Maastricht Study.

ABSTRACT:

Background

Altered white matter brain connectivity has been linked to depression. The aim of this study was to investigate the association of markers of white matter connectivity with prevalence, incidence and course of depressive symptoms.

Methods

Markers of white matter connectivity (node degree, clustering coefficient, local efficiency, characteristic path length, and global efficiency) were assessed at baseline by 3 T MRI in the population-based Maastricht Study (n = 4866; mean ± standard deviation age 59.6 ± 8.5 years, 49.0% women; 17 406 person-years of follow-up). Depressive symptoms (9-item Patient Health Questionnaire; PHQ-9) were assessed at baseline and annually over seven years of follow-up. Major depressive disorder (MDD) was assessed with the Mini-Intern

SUBMITTER: Geraets AFJ 

PROVIDER: S-EPMC10493191 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature