Relationship between paramacular thinning, cerebral vasculopathy, and hematological risk factors in sickle cell disease.

ABSTRACT:

Purpose

To identify risk factors for sickle cell maculopathy due to hematological parameters (especially anemia and hemolysis) or cerebral vasculopathy.

Methods

This retrospective study was conducted at a Referral Center. The follow-up included optical coherent tomography/optical coherent tomography angiography, neuro-radiological imaging, and a hematological assessment (hemoglobin, hemoglobin S level, reticulocytes, mean corpuscular volume, bilirubin, and lactate dehydrogenase).

Results

Hundred and thirty-two sickle cell patients were included. Maculopathy was observed in 127 eyes of SS patients and 10 eyes of SC patients (p < 0.001), unrelated to peripheral retinopathy. Cerebral vasculopathy was more frequent in SS patients (p < 0.001) an

SUBMITTER: Orssaud C 

PROVIDER: S-EPMC10493280 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature