Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties-a review.

ABSTRACT: Traditionally, selected plant sources have been explored for medicines to treat convulsions. This continues today, especially in countries with low-income rates and poor medical systems. However, in the low-income countries, plant extracts and isolated drugs are in high demand due to their good safety profiles. Preclinical studies on animal models of seizures/epilepsy have revealed the anticonvulsant and/or antiepileptogenic properties of, at least some, herb preparations or plant metabolites. Still, there is a significant number of plants known in traditional medicine that exert anticonvulsant activity but have not been evaluated on animal models. Zebrafish is recognized as a suitable in vivo model of epilepsy research and is increasingly used as a screening platform. In this revie

SUBMITTER: Knap B 

PROVIDER: S-EPMC10493295 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature