Divergent CD4⁺ T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients.

ABSTRACT:

Introduction

Acute myeloid leukemia (AML) is one of the commonest hematologic disorders. Due to the high frequency of disease- or treatment-related thrombocytopenia, AML requires treatment with multiple platelet transfusions, which can trigger a humoral response directed against platelets. Some, but not all, AML patients develop an anti-HLA immune response after multiple transfusions. We therefore hypothesized that different immune activation profiles might be associated with anti-HLA alloimmunization status.

Methods

We tested this hypothesis, by analyzing CD4+ T lymphocyte (TL) subsets and their immune control molecules in flow cytometry and single-cell multi-omics.

Results

A comparison of immunological status between anti-HLA alloimmunized and non-alloimmunized AML

SUBMITTER: Khelfa M 

PROVIDER: S-EPMC10493329 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature