Fecal occult blood and calprotectin testing to prioritize primary care patients for colonoscopy referral: The advantage study.

ABSTRACT:

Background

Colonoscopy is the gold standard for colorectal cancer (CRC) diagnosis and screening, but endoscopy services are usually overburdened. This study aims to investigate the usefulness of fecal hemoglobin (fHb) and calprotectin (FC) for the identification of patients with high probability of CRC who need urgent referral.

Methods

In a multicenter prospective study, we enrolled symptomatic patients referred from primary care for colonoscopy. Prior to bowel preparation, fHb and FC quantitative tests were performed. The diagnostic performance was estimated for each biomarker/combination. We built a multivariable predictive model based on logistic regression, translated to a nomogram and a risk calculator to assist clinicians in the decision-making process.

Results

SUBMITTER: Lanas A 

PROVIDER: S-EPMC10493338 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature