Smoking and colorectal neoplasia in patients with inflammatory bowel disease: Dose-effect relationship.

ABSTRACT:

Background and aims

Prior studies on the effect of smoking on the risk of colitis-associated colorectal neoplasia (CRN) have reported conflicting results. We aimed to further elucidate the association between smoking, including possible dose-effects, and the development of colorectal neoplasia in patients with inflammatory bowel disease (IBD).

Methods

We performed a prospective multicenter cohort study including patients with colonic IBD enrolled in a surveillance program in four academic hospitals between 2011 and 2021. The effects of smoking status and pack-years at study entry on subsequent recurrent events of CRN (including indefinite, low- and high-grade dysplasia, and colorectal cancer [CRC]) were evaluated using uni- and multivariable Prentice, Williams, and Peterson

SUBMITTER: Wijnands AM 

PROVIDER: S-EPMC10493358 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature