The impact of antimicrobial de-escalation therapy in culture-negative pneumonia: a systematic review and meta-analysis.

ABSTRACT:

Background/aims

Antimicrobial de-escalation (ADE) remains a challenging strategy in the treatment of pneumonia. We investigated the outcomes of ADE as measured by mortality and duration of the use of antibiotics in patients with culture- negative pneumonia.

Methods

We performed a systematic review and meta-analysis in accordance with PRISMA guidelines. The primary outcome was inpatient mortality.

Results

We examined six studies comprising 11,933 subjects, of whom 1,152 received ADE. Overall, the ADE strategy was associated with a statistically lower risk of in-hospital mortality compared with non-ADE (risk ratio [RR] = 0.60, 95% confidence interval [CI] = 0.38 to 0.93). Although substantial heterogeneity was found among the included studies (I2 = 66%), a meta-regressi

SUBMITTER: Song JU 

PROVIDER: S-EPMC10493446 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature