Drooling disrupts the brain functional connectivity network in Parkinson's disease.

ABSTRACT:

Aims

This study aimed to investigate the causal interaction between significant sensorimotor network (SMN) regions and other brain regions in Parkinson's disease patients with drooling (droolers).

Methods

Twenty-one droolers, 22 PD patients without drooling (non-droolers), and 22 matched healthy controls underwent 3T-MRI resting-state scans. We performed independent component analysis and Granger causality analysis to determine whether significant SMN regions help predict other brain areas. Pearson's correlation was computed between imaging characteristics and clinical characteristics. ROC curves were plotted to assess the diagnostic performance of effective connectivity (EC).

Results

Compared with non-droolers and healthy controls, droolers showed abnormal EC of the

SUBMITTER: Huang T 

PROVIDER: S-EPMC10493659 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature