Association of coffee consumption and striatal volume in patients with Parkinson's disease and healthy controls.

ABSTRACT:

Background

Mounting studies have demonstrated that coffee consumption significantly reduces the risk of developing Parkinson's disease (PD). However, there have been few investigations about the role of chronic coffee consumption in nigrostriatal structural neurodegeneration in PD. We aimed to investigate whether chronic coffee consumption is associated with the change in striatal volume in PD.

Methods

In this study, 130 de novo patients with PD and 69 healthy controls were enrolled from the Parkinson's Progression Markers Initiative cohort. Patients with PD and healthy controls were, respectively, divided into three subgroups, including current, ever, and never coffee consumers. Then, striatal volume was compared across the three subgroups. Correlation analyses were perform

SUBMITTER: Wang C 

PROVIDER: S-EPMC10493673 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature