Histological examination of renal nerve distribution, density, and function in humans.

ABSTRACT:

Background

Renal denervation is optimised when guided by knowledge of nerve distribution.

Aims

We aimed to assess sympathetic nerve distribution along the renal arteries, especially in post-bifurcation vessel segments.

Methods

Renal arteries and surrounding tissue from 10 body donors were collected and examined histologically. Immunohistochemical staining was used to analyse nerve distribution and to identify afferent and efferent sympathetic nerves.

Results

A total of 6,781 nerves surrounding 18 renal arteries were evaluated. The mean lumen-nerve distance of the left renal artery (2.32±1.95 mm) was slightly greater than the right (2.29±2.03 mm; p=0.161); this varied across the arteries' courses: 3.7±2.3 mm in proximal segments, 2.5±2.0 mm in middle segments, 1

SUBMITTER: Struthoff H 

PROVIDER: S-EPMC10493771 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature