Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.

ABSTRACT:

Background

Ultrasound and radiofrequency renal denervation (RDN) have been shown to safely lower blood pressure (BP) in hypertension.

Aims

The TARGET BP OFF-MED trial investigated the efficacy and safety of alcohol-mediated renal denervation (RDN) in the absence of antihypertensive medications.

Methods

This randomised, blinded, sham-controlled trial was conducted in 25 centres in Europe and the USA. Patients with a 24-hour systolic BP of 135-170 mmHg, an office systolic BP 140-180 mmHg and diastolic BP ≥90 mmHg on 0-2 antihypertensive medications were enrolled. The primary efficacy endpoint was the change in mean 24-hour systolic BP at 8 weeks. Safety endpoints included major adverse events up to 30 days.

Results

A total of 106 patients were randomised; the bas

SUBMITTER: Pathak A 

PROVIDER: S-EPMC10493775 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature